DNA methylation biomarkers accurately detect esophageal cancer prior and post neoadjuvant chemoradiation.

ABSTRACT:

Background

Esophageal cancer (ECa) is associated with high mortality, mostly due to late diagnosis, precluding curativeintent surgery. Hence, neoadjuvant chemoradiation (ChRT) is recommended in most patients regardless of histological subtype. A proportion of these patients, however, achieve complete disease remission and might be spared of radical surgery. The lack of reliable, minimally invasive biomarkers able to detect post-ChRT disease persistence is, nonetheless, a major drawback. We have previously shown that miRNA promotor methylation enables accurate cancer detection in tissues and liquid biopsies but has been seldom explored in ECa patients.

Aims

Herein, we sought to unveil and validate novel candidate biomarkers able to detect ECa prior and post ChRT.

Materials

SUBMITTER: Macedo-Silva C 

PROVIDER: S-EPMC10134363 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature