Diagnosis, treatment, and prognosis of primary intraocular lymphoma: Single-center real-world clinical experience.

ABSTRACT:

Background

The diagnosis and management of primary intraocular lymphoma (PIOL) remain challenging. This study identified factors indicative of PIOL, described treatment outcomes, and determined modalities to prevent relapse.

Methods

We included 21 PIOL-diagnosed patients, seven via cytology, 12 via genetic evaluation, and two via interleukin (IL) level measurements, who underwent vitrectomy and received local intravitreal methotrexate (IV-MTX) injection. Clinical outcomes, including treatment response and relapse, were compared between patients receiving IV-MTX alone (n = 13) or IV-MTX with systemic high-dose methotrexate (HD-MTX) as prophylaxis (n = 8).

Results

Twelve ophthalmologic and eight central nervous system (CNS) relapse cases within a median of 20.3 and 11.6

SUBMITTER: Min GJ 

PROVIDER: S-EPMC10134376 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature