Systematic altering of semiflexible DNA-based polymer networks via tunable crosslinking.

ABSTRACT: In order to understand and predict the mechanical behaviours of complex, soft biomaterials such as cells or stimuli-responsive hydrogels, it is important to connect how the nanoscale properties of their constituent components impact those of the bulk material. Crosslinked networks of semiflexible polymers are particularly ubiquitous, being underlying mechanical components of biological systems such as cells or ECM, as well as many synthetic or biomimetic materials. Cell-derived components such as filamentous biopolymers or protein crosslinkers are readily available and well-studied model systems. However, as evolutionarily derived materials, they are constrained to a fixed set of structural parameters such as the rigidity and size of the filaments, or the valency and strength of binding of

SUBMITTER: Glaser M 

PROVIDER: S-EPMC10134436 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature