Early identification of treatment non-response in first-episode psychosis.

ABSTRACT:

Background

Approximately one-third of patients with psychotic disorders does not respond to standard antipsychotic treatments. Consensus criteria for treatment resistance (TR) may aid the identification of non-response and subsequent tailoring of treatments. Since consensus criteria require stability of clinical status, they are challenging to apply in first-episode psychosis (FEP). This study aims to investigate (a) if an adaptation of consensus criteria can be used to identify FEP patients with early signs of TR (no early clinical recovery-no-ECR) after 1 year in treatment and (b) to what extent differences in antipsychotic treatments differentiate between outcome groups.

Methods

Participants with FEP DSM-IV schizophrenia spectrum disorders were recruited during their firs

SUBMITTER: Wold KF 

PROVIDER: S-EPMC10134449 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature