25(OH)Vitamin D and autism spectrum disorder: genetic overlap and causality.

ABSTRACT:

Objective

To identify whether there exists a genetic correlation and causal relationship between 25(OH)D and autism spectrum disorder (ASD).

Methods

Based on large-scale genome-wide association studies, a series of genetic approaches were adopted to obtain summary statistics. Using linkage disequilibrium score regression, we assessed the shared polygenic structure between traits and performed pleiotropic analysis under composite null hypothesis (PLACO) to identify pleiotropic loci between complex traits. A bidirectional Mendelian randomization (MR) analysis was applied to investigate whether there is a causal relationship between 25(OH)D and ASD.

Results

The linkage disequilibrium score regression (LDSC) showed a negative genetic correlation between 25(OH)D and ASD (r

SUBMITTER: Yu G 

PROVIDER: S-EPMC10134540 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature