TP53 somatic mutations in Asian breast cancer are associated with subtype-specific effects.

ABSTRACT:

Background

Recent genomics studies of breast cancer in Asian cohorts have found a higher prevalence of TP53 mutations in Asian breast cancer patients relative to Caucasian patients. However, the effect of TP53 mutations on Asian breast tumours has not been comprehensively studied.

Methods

Here, we report an analysis of 492 breast cancer samples from the Malaysian Breast Cancer cohort where we examined the impact of TP53 somatic mutations in relation to PAM50 subtypes by comparing whole exome and transcriptome data from tumours with mutant and wild-type TP53.

Results

We found that the magnitude of impact of TP53 somatic mutations appears to vary between different subtypes. TP53 somatic mutations were associated with higher HR deficiency scores as well as greater upregu

SUBMITTER: Ragu ME 

PROVIDER: S-EPMC10134541 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature