Protection of melatonin treatment and combination with traditional antibiotics against septic myocardial injury.

ABSTRACT:

Background

Heart failure is a common complication of sepsis with a high mortality rate. It has been reported that melatonin can attenuate septic injury due to various properties. On the basis of previous reports, this study will further explore the effects and mechanisms of melatonin pretreatment, posttreatment, and combination with antibiotics in the treatment of sepsis and septic myocardial injury.

Methods and results

Our results showed that melatonin pretreatment showed an obvious protective effect on sepsis and septic myocardial injury, which was related to the attenuation of inflammation and oxidative stress, the improvement of mitochondrial function, the regulation of endoplasmic reticulum stress (ERS), and the activation of the AMPK signaling pathway. In particular, A

SUBMITTER: Di W 

PROVIDER: S-EPMC10134561 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature