Mesenchymal stem cells transplantation for perianal fistulas: a systematic review and meta-analysis of clinical trials.

ABSTRACT: Perianal fistulas, characterised as granulomatous inflammation of fistulas around the anal canal, are associated with significant morbidity resulting in a negative impact on quality of life and a tremendous burden to the healthcare system. Treatment of anal fistulas usually consists of anal surgery; however, results of closure rates are not satisfactory especially with complex perianal fistulas, after which many patients may suffer from anal incontinence. Recently, the administration of mesenchymal stem cells (MSCs) has shown promising efficacy. Herein, we aim to explore whether MSCs are effective for complex perianal fistulas and if they have either short-term, medium-term, long-term or over-long-term efficacy. Additionally, we want to elucidate whether factors such as drug dosage, MSC so

SUBMITTER: Wang H 

PROVIDER: S-EPMC10134595 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature