Prominent epigenetic and transcriptomic changes in CD4⁺ and CD8⁺ T cells during and after pregnancy in women with multiple sclerosis and controls.

ABSTRACT:

Background

Multiple sclerosis (MS) is a neuroinflammatory disease in which pregnancy leads to a temporary amelioration in disease activity as indicated by the profound decrease in relapses rate during the 3rd trimester of pregnancy. CD4⁺ and CD8⁺ T cells are implicated in MS pathogenesis as being key regulators of inflammation and brain lesion formation. Although Tcells are prime candidates for the pregnancy-associated improvement of MS, the precise mechanisms are yet unclear, and in particular, a deep characterization of the epigenetic and transcriptomic events that occur in peripheral T cells during pregnancy in MS is lacking.

Methods

Women with MS and healthy controls were longitudinally sampled before, during (1st, 2nd and 3rd trimesters) and after

SUBMITTER: Zenere A 

PROVIDER: S-EPMC10134602 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature