Down-regulation of ERAP1 mRNA expression in non-small cell lung cancer.

ABSTRACT:

Background

ERAP1 is a major aminopeptidase that serves as an editor of the peptide repertoire by trimming N-terminal residues of antigenic peptides, creating a pool of peptides with the optimal length for MHC-I binding. As an important component of the antigen processing and presenting machinery - APM, ERAP1 is frequently down-regulated in many cancers. Since ERAP1 expression has not yet been thoroughly investigated in non-small cell lung cancer (NSCLC), we decided to analyze ERAP1 mRNA levels in tissues collected from NSCLC patients.

Methods

Using real-time qPCR, we evaluated ERAP1 mRNA expression in samples of tumor and adjacent non-tumor tissue (serving as control tissue) from 61 NSCLC patients.

Results

We observed a significantly lower level of ERAP1 mRNA expressi

SUBMITTER: Wagner M 

PROVIDER: S-EPMC10134604 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature