Sex-dependent gut microbiota-brain-cognition associations: a multimodal MRI study.

ABSTRACT:

Background

There is bidirectional communication between the gut microbiota and the brain. Empirical evidence has demonstrated sex differences in both the gut microbiome and the brain. However, the effects of sex on the gut microbiota-brain associations have yet to be determined. We aim to elucidate the sex-specific effects of gut microbiota on brain and cognition.

Methods

One hundred fifty-seven healthy young adults underwent brain structural, perfusion, functional and diffusion MRIs to measure gray matter volume (GMV), cerebral blood flow (CBF), functional connectivity strength (FCS) and white matter integrity, respectively. Fecal samples were collected and 16S amplicon sequencing was utilized to assess gut microbial diversity. Correlation analyses were conducted to test fo

SUBMITTER: Zhang S 

PROVIDER: S-EPMC10134644 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature