Principal component analysis of adipose tissue gene expression of lipogenic and adipogenic factors in obesity.

ABSTRACT:

Objective

A better understanding of mechanisms regulating lipogenesis and adipogenesis is needed to overcome the obesity pandemic. We aimed to study the relationship of the transcript levels of peroxisome proliferator activator receptor γ (PPARγ), CCAAT/enhancer-binding protein alpha (C/EBP-α), liver X receptor (LXR), sterol regulatory element-binding protein-1c (SREBP-1c), fatty acid synthase (FAS), and acetyl-CoA carboxylase (ACC) in subcutaneous adipose tissue (SAT) and visceral adipose tissue (VAT) from obese and normal-weight women with a variety of anthropometric indices, metabolic and biochemical parameters, and insulin resistance.

Methods

Real-time PCR was done to evaluate the transcript levels of the above-mentioned genes in VAT and SAT from all participants.

Res

SUBMITTER: Jannat Ali Pour N 

PROVIDER: S-EPMC10134674 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature