Accurate detection of early-stage lung cancer using a panel of circulating cell-free DNA methylation biomarkers.

ABSTRACT:

Background

Lung cancer remains the leading cause of cancer mortality worldwide. Early detection of lung cancer helps improve treatment and survival. Numerous aberrant DNA methylations have been reported in early-stage lung cancer. Here, we sought to identify novel DNA methylation biomarkers that could potentially be used for noninvasive early diagnosis of lung cancers.

Methods

This prospective-specimen collection and retrospective-blinded-evaluation trial enrolled a total of 317 participants (198 tissues and 119 plasmas) comprising healthy controls, patients with lung cancer and benign disease between January 2020 and December 2021. Tissue and plasma samples were subjected to targeted bisulfite sequencing with a lung cancer specific panel targeting 9,307 differential methyla

SUBMITTER: Hu S 

PROVIDER: S-EPMC10134678 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature