The Alterations of Gut Microbiome and Lipid Metabolism in Patients with Spinal Muscular Atrophy.

ABSTRACT:

Introduction

Spinal muscular atrophy (SMA) can cause multiple system dysfunction, especially lipid metabolic disorders, for which management strategies are currently lacking. Microbes are related to metabolism and the pathogenesis of neurological diseases. This study aimed to preliminarily explore the alterations in the gut microbiota in SMA and the potential relationship between altered microbiota and lipid metabolic disorders.

Methods

Fifteen patients with SMA and 17 gender- and age-matched healthy controls were enrolled in the study. Feces and fasting plasma samples were collected. 16S ribosomal RNA sequencing and nontargeted metabolomics analysis were performed to explore the correlation between microbiota and differential lipid metabolites.

Results

No significant

SUBMITTER: Feng Y 

PROVIDER: S-EPMC10134726 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature