Modeling RBE with other quantities than LET significantly improves prediction of in vitro cell survival for proton therapy.

ABSTRACT:

Background

For proton therapy, a relative biological effectiveness (RBE) of 1.1 has broadly been applied clinically. However, as unexpected toxicities have been observed by the end of the proton tracks, variable RBE models have been proposed. Typically, the dose-averaged linear energy transfer (LET_d ) has been used as an input variable for these models but the way the LET_d was defined, calculated, or determined was not always consistent, potentially impacting the corresponding RBE value.

Purpose

This study compares consistently calculated LET_d with other quantities as input variables for a phenomenological RBE model and attempts to determine which quantity that can best predicts proton RBE. The comparison was performed within the frame of int

SUBMITTER: Kalholm F 

PROVIDER: S-EPMC10134779 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature