Consistent Stool Metagenomic Biomarkers Associated with the Response To Melanoma Immunotherapy.

ABSTRACT: The human gut microbiome plays an important role in both health and disease. Recent studies have demonstrated a strong influence of the gut microbiome composition on the efficacy of cancer immunotherapy. However, available studies have not yet succeeded in finding reliable and consistent metagenomic markers that are associated with the response to immunotherapy. Therefore, the reanalysis of the published data may improve our understanding of the association between the composition of the gut microbiome and the treatment response. In this study, we focused on melanoma-related metagenomic data, which are more abundant than are data from other tumor types. We analyzed the metagenomes of 680 stool samples from 7 studies that were published earlier. The taxonomic and functional biomarkers were

SUBMITTER: Olekhnovich EI 

PROVIDER: S-EPMC10134792 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature