Natural Green Spaces, Sensitization to Allergens, and the Role of Gut Microbiota during Infancy.

ABSTRACT: The environment plays an instrumental role in the developmental origins of health and disease. Protective features of the environment in the development of asthma and atopy have been insufficiently studied. We used data from the CHILD (Canadian Healthy Infant Longitudinal Development) Cohort Study to examine relationships between living near natural green spaces in early infancy in Edmonton, AB, Canada and the development of atopic sensitization at 1 year and 3 years of age in a cohort of 699 infants, and whether these associations were mediated by infant gut microbiota (measured using 16s V4 amplicon sequencing) at 4 months. The Urban Planning Land Vegetation Index (uPLVI) map of the City of Edmonton was used to assess infants' exposure to natural spaces based on their home postal codes,

SUBMITTER: Buchholz V 

PROVIDER: S-EPMC10134798 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature