Convergent Within-Host Adaptation of Pseudomonas aeruginosa through the Transcriptional Regulatory Network.

ABSTRACT: Bacteria adapt to their host by mutating specific genes and by reprogramming their gene expression. Different strains of a bacterial species often mutate the same genes during infection, demonstrating convergent genetic adaptation. However, there is limited evidence for convergent adaptation at the transcriptional level. To this end, we utilize genomic data of 114 Pseudomonas aeruginosa strains, derived from patients with chronic pulmonary infection, and the P. aeruginosa transcriptional regulatory network. Relying on loss-of-function mutations in genes encoding transcriptional regulators and predicting their effects through the network, we demonstrate predicted expression changes of the same genes in different strains through different paths in the network, implying convergent transcripti

SUBMITTER: Gatt YE 

PROVIDER: S-EPMC10134825 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature