Cell-Intrinsic CD38 Expression Sustains Exhausted CD8⁺ T Cells by Regulating Their Survival and Metabolism during Chronic Viral Infection.

ABSTRACT: Acute and chronic viral infections result in the differentiation of effector and exhausted T cells with functional and phenotypic differences that dictate whether the infection is cleared or progresses to chronicity. High CD38 expression has been observed on CD8⁺ T cells across various viral infections and tumors in patients, suggesting an important regulatory function for CD38 on responding T cells. Here, we show that CD38 expression was increased and sustained on exhausted CD8⁺ T cells following chronic lymphocytic choriomeningitis virus (LCMV) infection, with lower levels observed on T cells from acute LCMV infection. We uncovered a cell-intrinsic role for CD38 expression in regulating the survival of effector and exhausted CD8⁺ T cells. We observed incr

SUBMITTER: DeRogatis JM 

PROVIDER: S-EPMC10134879 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature