A Genome-Scale Atlas Reveals Complex Interplay of Transcription and Translation in an Archaeon.

ABSTRACT: The scale of post-transcriptional regulation and the implications of its interplay with other forms of regulation in environmental acclimation are underexplored for organisms of the domain Archaea. Here, we have investigated the scale of post-transcriptional regulation in the extremely halophilic archaeon Halobacterium salinarum NRC-1 by integrating the transcriptome-wide locations of transcript processing sites (TPSs) and SmAP1 binding, the genome-wide locations of antisense RNAs (asRNAs), and the consequences of RNase_2099C knockout on the differential expression of all genes. This integrated analysis has discovered that 54% of all protein-coding genes in the genome of this haloarchaeon are likely targeted by multiple mechanisms for putative post-transcriptional processing and reg

SUBMITTER: Lorenzetti APR 

PROVIDER: S-EPMC10134880 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature