The Importance of Being RNA-est: considering RNA-mediated ribosome plasticity.

ABSTRACT: For over 40 years, ribosomes were considered monolithic machines that translate the genetic code indiscriminately. However, over the past two decades, there have been a growing number of studies that suggest ribosomes to have a degree of compositional and functional adaptability in response to tissue type, cell environment and stimuli, cell cycle or development state. In such form, ribosomes themselves take an active part in translation regulation through an intrinsic adaptability provided by evolution, which furnished ribosomes with a dynamic plasticity that confers another layer of gene expression regulation. Yet despite the identification of various sources that give rise to ribosomal heterogeneity both at the protein and RNA level, its functional relevance is still debated, and many qu

SUBMITTER: Trahan C 

PROVIDER: S-EPMC10134959 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature