Worldwide Dissemination of bla_KPC Gene by Novel Mobilization Platforms in Pseudomonas aeruginosa: A Systematic Review.

ABSTRACT: The dissemination of bla_KPC-harboring Pseudomonas aeruginosa (KPC-Pa) is considered a serious public health problem. This study provides an overview of the epidemiology of these isolates to try to elucidate novel mobilization platforms that could contribute to their worldwide spread. A systematic review in PubMed and EMBASE was performed to find articles published up to June 2022. In addition, a search algorithm using NCBI databases was developed to identify sequences that contain possible mobilization platforms. After that, the sequences were filtered and pair-aligned to describe the bla_KPC genetic environment. We found 691 KPC-Pa isolates belonging to 41 different sequence types and recovered from 14 countries. Although the bla<

SUBMITTER: Forero-Hurtado D 

PROVIDER: S-EPMC10134989 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature