Matrix Metalloproteinase 13 Is Associated with Age-Related Choroidal Neovascularization.

ABSTRACT: Age-related macular degeneration (AMD) is a leading cause of severe vision loss in older individuals in developed countries. Despite advances in our understanding of AMD, its pathophysiology remains poorly understood. Matrix metalloproteinases (MMPs) have been proposed to play a role in AMD development. In this study, we aimed to characterize MMP-13 in AMD. We used retinal pigment epithelial cells, a murine model of laser-induced choroidal neovascularization, and plasma samples from patients with neovascular AMD to conduct our study. Our results show that MMP13 expression significantly increased under oxidative stress conditions in cultured retinal pigment epithelial cells. In the murine model, MMP13 was overexpressed in both retinal pigment epithelial cells and endothelial cells during ch

SUBMITTER: Gonzalez-Zamora J 

PROVIDER: S-EPMC10135211 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature