Rhodanese-Fold Containing Proteins in Humans: Not Just Key Players in Sulfur Trafficking.

ABSTRACT: The Rhodanese-fold is a ubiquitous structural domain present in various protein subfamilies associated with different physiological functions or pathophysiological conditions in humans. Proteins harboring a Rhodanese domain are diverse in terms of domain architecture, with some representatives exhibiting one or several Rhodanese domains, fused or not to other structural domains. The most famous Rhodanese domains are catalytically active, thanks to an active-site loop containing an essential cysteine residue which allows for catalyzing sulfur transfer reactions involved in sulfur trafficking, hydrogen sulfide metabolism, biosynthesis of molybdenum cofactor, thio-modification of tRNAs or protein urmylation. In addition, they also catalyse phosphatase reactions linked to cell cycle regulation

SUBMITTER: Alsohaibani R 

PROVIDER: S-EPMC10135228 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature