Targeting BAM for Novel Therapeutics against Pathogenic Gram-Negative Bacteria.

ABSTRACT: The growing emergence of multidrug resistance in bacterial pathogens is an immediate threat to human health worldwide. Unfortunately, there has not been a matching increase in the discovery of new antibiotics to combat this alarming trend. Novel contemporary approaches aimed at antibiotic discovery against Gram-negative bacterial pathogens have expanded focus to also include essential surface-exposed receptors and protein complexes, which have classically been targeted for vaccine development. One surface-exposed protein complex that has gained recent attention is the β-barrel assembly machinery (BAM), which is conserved and essential across all Gram-negative bacteria. BAM is responsible for the biogenesis of β-barrel outer membrane proteins (β-OMPs) into the outer membrane. These β-OMPs s

SUBMITTER: Overly Cottom C 

PROVIDER: S-EPMC10135246 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature