The Influence of 5',8-Cyclo-2'-Deoxyguanosine on ds-DNA Charge Transfer Depends on Its Diastereomeric Form: A Theoretical Study.

ABSTRACT: The genetic information stored in the nucleobase sequence is continuously exposed to harmful extra- and intra-cellular factors, which can lead to different types of DNA damage, with more than 70 lesion types identified so far. In this article, the influence of a multi-damage site containing (5'R/S) 5',8-cyclo-2'-deoxyguanosine (cdG) and 7,8-dihydro-8-oxo-2'-deoxyguanosine (^OXOdG) on charge transfer through ds-DNA was taken into consideration. The spatial geometries of oligo-RcdG: d[A₁(5'R)cG₂A₃^OXOG₄A₅]*d[T₅C₄T₃C₂T₁] and oligo-ScdG: d[A₁(5'S)cG₂A₃^OXOG₄A₅]*d[T₅

SUBMITTER: Karwowski BT 

PROVIDER: S-EPMC10135346 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature