Oxidative Stress and Epigenetics: miRNA Involvement in Rare Autoimmune Diseases.

ABSTRACT: Autoimmune diseases (ADs) such as Sjögren's syndrome, Kawasaki disease, and systemic sclerosis are characterized by chronic inflammation, oxidative stress, and autoantibodies, which cause joint tissue damage, vascular injury, fibrosis, and debilitation. Epigenetics participate in immune cell proliferation and differentiation, which regulates the development and function of the immune system, and ultimately interacts with other tissues. Indeed, overlapping of certain clinical features between ADs indicate that numerous immunologic-related mechanisms may directly participate in the onset and progression of these diseases. Despite the increasing number of studies that have attempted to elucidate the relationship between miRNAs and oxidative stress, autoimmune disorders and oxidative stress, a

SUBMITTER: Ibanez-Cabellos JS 

PROVIDER: S-EPMC10135388 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature