A post-transcriptional regulatory landscape of aging in the female mouse hippocampus.

ABSTRACT: Aging is associated with substantial physiological changes and constitutes a major risk factor for neurological disorders including dementia. Alterations in gene expression upon aging have been extensively studied; however, an in-depth characterization of post-transcriptional regulatory events remains elusive. Here, we profiled the age-related changes of the transcriptome and translatome in the female mouse hippocampus by RNA sequencing of total RNA and polysome preparations at four ages (3-, 6-, 12-, 20-month-old); and we implemented a variety of bioinformatics approaches to unravel alterations in transcript abundance, alternative splicing, and polyadenylation site selection. We observed mostly well-coordinated transcriptome and translatome expression signatures across age including upreg

SUBMITTER: Winsky-Sommerer R 

PROVIDER: S-EPMC10135431 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature