Risk factors for clonal hematopoiesis of indeterminate potential and mosaic chromosomal alterations.

ABSTRACT: Clonal hematopoiesis of indeterminate potential (CHIP) and mosaic chromosomal alterations (mCAs) of the autosomes, X, and Y chromosomes are aging-related somatic mutations detectable in peripheral blood. The presence of these acquired mutations predisposes otherwise healthy adults to increased risk of several chronic aging-related conditions including hematologic cancers, atherosclerotic cardiovascular diseases, other inflammatory conditions, and mortality. While the public health impact and disease associations of these blood-derived somatic mutations continue to expand, the inherited, behavioral/lifestyle, environmental risk factors and comorbid conditions that influence their occurrence and progression have been less well characterized. Age is the strongest risk factor for all types of

SUBMITTER: Jakubek YA 

PROVIDER: S-EPMC10135440 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature