NR3C1 rs6198 Variant May Be Involved in the Relationship of Graves' Disease with Stressful Events.

ABSTRACT: Although stressful events are known to trigger Graves' disease (GD), the mechanisms involved in this process are not well understood. The NR3C1 gene, encoding for the glucocorticoid receptor (GR), presents single nucleotide polymorphisms (SNPs) that are associated with stress-related diseases. To investigate the relationship between NR3C1 SNPs, GD susceptibility, and clinical features, we studied 792 individuals, including 384 patients, among which 209 presented with Graves' orbitopathy (GO), and 408 paired healthy controls. Stressful life events were evaluated in a subset of 59 patients and 66 controls using the IES-R self-report questionnaire. SNPs rs104893913, rs104893909, and rs104893911 appeared at low frequencies and presented similar profiles in patients and controls.

SUBMITTER: Nascimento M 

PROVIDER: S-EPMC10135546 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature