The N-Glycosylation of Total Plasma Proteins and IgG in Atrial Fibrillation.

ABSTRACT: Atrial fibrillation is a disease with a complex pathophysiology, whose occurrence and persistence are caused not only by aberrant electrical signaling in the heart, but by the development of a susceptible heart substrate. These changes, such as the accumulation of adipose tissue and interstitial fibrosis, are characterized by the presence of inflammation. N-glycans have shown great promise as biomarkers in different diseases, specifically those involving inflammatory changes. To assess the changes in the N-glycosylation of the plasma proteins and IgG in atrial fibrillation, we analyzed the N-glycosylation of 172 patients with atrial fibrillation, before and six months after a pulmonary vein isolation procedure, with 54 cardiovascularly healthy controls. An analysis was

SUBMITTER: Plavsa B 

PROVIDER: S-EPMC10135591 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature