Circular RNA Expression Profiling by Microarray-A Technical and Practical Perspective.

ABSTRACT: Circular RNAs, as covalently circularized RNA loops, have many unique biochemical properties. Many circRNA biological functions and clinical indications are being continually discovered. Increasingly, circRNAs are being used as a new class of biomarkers, which are potentially superior to linear RNAs due to the unusual cell/tissue/disease specificities and the exonuclease-resistant stabilized circular form in the biofluids. Profiling circRNA expression has been a common step in circRNA research to provide much needed insight into circRNA biology and to facilitate rapid advances in the circRNA field. We will review circRNA microarrays as a practical and effective circRNA profiling technology for regularly equipped biological or clinical research labs, share valuable experiences, and highligh

SUBMITTER: Shi Y 

PROVIDER: S-EPMC10135611 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature