Mitochondrial Dynamics as Potential Modulators of Hormonal Therapy Effectiveness in Males.

ABSTRACT: Worldwide the incidence of andrological diseases is rising every year and, together with it, also the interest in them is increasing due to their strict association with disorders of the reproductive system, including impairment of male fertility, alterations of male hormones production, and/or sexual function. Prevention and early diagnosis of andrological dysfunctions have long been neglected, with the consequent increase in the incidence and prevalence of diseases otherwise easy to prevent and treat if diagnosed early. In this review, we report the latest evidence of the effect of andrological alterations on fertility potential in both young and adult patients, with a focus on the link between gonadotropins' mechanism of action and mitochondria. Indeed, mitochondria are highly dynamic c

SUBMITTER: Errico A 

PROVIDER: S-EPMC10135745 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature