Modeling the Circadian Control of the Cell Cycle and Its Consequences for Cancer Chronotherapy.

ABSTRACT: The mammalian cell cycle is governed by a network of cyclin/Cdk complexes which signal the progression into the successive phases of the cell division cycle. Once coupled to the circadian clock, this network produces oscillations with a 24 h period such that the progression into each phase of the cell cycle is synchronized to the day-night cycle. Here, we use a computational model for the circadian clock control of the cell cycle to investigate the entrainment in a population of cells characterized by some variability in the kinetic parameters. Our numerical simulations showed that successful entrainment and synchronization are only possible with a sufficient circadian amplitude and an autonomous period close to 24 h. Cellular heterogeneity, however, introduces some variability in the entr

SUBMITTER: Leung C 

PROVIDER: S-EPMC10135823 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature