Autoimmunity and Carcinogenesis: Their Relationship under the Umbrella of Autophagy.

ABSTRACT: The immune system and autophagy share a functional relationship. Both innate and adaptive immune responses involve autophagy and, depending on the disease's origin and pathophysiology, it may have a detrimental or positive role on autoimmune disorders. As a "double-edged sword" in tumors, autophagy can either facilitate or impede tumor growth. The autophagy regulatory network that influences tumor progression and treatment resistance is dependent on cell and tissue types and tumor stages. The connection between autoimmunity and carcinogenesis has not been sufficiently explored in past studies. As a crucial mechanism between the two phenomena, autophagy may play a substantial role, though the specifics remain unclear. Several autophagy modifiers have demonstrated beneficial effects in model

SUBMITTER: Muzes G 

PROVIDER: S-EPMC10135912 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature