Glucocorticoid Receptor and Ovarian Cancer: From Biology to Therapeutic Intervention.

ABSTRACT: Ovarian cancer (OC) is the leading cause of death from gynecological malignancies worldwide. Fortunately, recent advances in OC biology and the discovery of novel therapeutic targets have led to the development of novel therapeutic agents that may improve the outcome of OC patients. The glucocorticoid receptor (GR) is a ligand-dependent transcriptional factor known for its role in body stress reactions, energy homeostasis and immune regulation. Notably, evidence suggests that GR may play a relevant role in tumor progression and may affect treatment response. In cell culture models, administration of low levels of glucocorticoids (GCs) suppresses OC growth and metastasis. Conversely, high GR expression has been associated with poor prognostic features and long-term outcomes in patients with

SUBMITTER: Buonaiuto R 

PROVIDER: S-EPMC10135974 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature