Antimicrobial Peptides (AMPs): Potential Therapeutic Strategy against Trypanosomiases?

ABSTRACT: Trypanosomiases are a group of tropical diseases that have devastating health and socio-economic effects worldwide. In humans, these diseases are caused by the pathogenic kinetoplastids Trypanosoma brucei, causing African trypanosomiasis or sleeping sickness, and Trypanosoma cruzi, causing American trypanosomiasis or Chagas disease. Currently, these diseases lack effective treatment. This is attributed to the high toxicity and limited trypanocidal activity of registered drugs, as well as resistance development and difficulties in their administration. All this has prompted the search for new compounds that can serve as the basis for the development of treatment of these diseases. Antimicrobial peptides (AMPs) are small peptides synthesized by both prokaryotes and (unicellular

SUBMITTER: Rojas-Pirela M 

PROVIDER: S-EPMC10135997 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature