Further Investigations of Nitroheterocyclic Compounds as Potential Antikinetoplastid Drug Candidates.

ABSTRACT: Due to the lack of specific vaccines, management of the trypanosomatid-caused neglected tropical diseases (sleeping sickness, Chagas disease and leishmaniasis) relies exclusively on pharmacological treatments. Current drugs against them are scarce, old and exhibit disadvantages, such as adverse effects, parenteral administration, chemical instability and high costs which are often unaffordable for endemic low-income countries. Discoveries of new pharmacological entities for the treatment of these diseases are scarce, since most of the big pharmaceutical companies find this market unattractive. In order to fill the pipeline of compounds and replace existing ones, highly translatable drug screening platforms have been developed in the last two decades. Thousands of molecules have been tested

SUBMITTER: Garcia-Estrada C 

PROVIDER: S-EPMC10136037 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature