Cu⁺/Ag⁺ Competition in Type I Copper Proteins (T1Cu).

ABSTRACT: Due to the similarity in the basic coordination behavior of their mono-charged cations, silver biochemistry is known to be linked to that of copper in biological systems. Still, Cu⁺/²⁺ is an essential micronutrient in many organisms, while no known biological process requires silver. In human cells, copper regulation and trafficking is strictly controlled by complex systems including many cytosolic copper chaperones, whereas some bacteria exploit the so-called "blue copper" proteins. Therefore, evaluating the controlling factors of the competition between these two metal cations is of enormous interest. By employing the tools of computational chemistry, we aim to delineate the extent to which Ag⁺ might be able to compete with the endogenous copper in its Ty

SUBMITTER: Kircheva N 

PROVIDER: S-EPMC10136078 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature