Potential Molecular Mechanisms of Alzheimer's Disease from Genetic Studies.

ABSTRACT: The devastating effects of Alzheimer's disease (AD) are yet to be ameliorated due to the absence of curative treatment options. AD is an aging-related disease that affects cognition, and molecular imbalance is one of its hallmarks. There is a need to identify common causes of molecular imbalance in AD and their potential mechanisms for continuing research. A narrative synthesis of molecular mechanisms in AD from primary studies that employed single-cell sequencing (scRNA-seq) or spatial genomics was conducted using Embase and PubMed databases. We found that differences in molecular mechanisms in AD could be grouped into four key categories: sex-specific features, early-onset features, aging, and immune system pathways. The reported causes of molecular imbalance were alterations in bile aci

SUBMITTER: Nwadiugwu M 

PROVIDER: S-EPMC10136191 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature