Mouse CCL9 Chemokine Acts as Tumor Suppressor in a Murine Model of Colon Cancer.

ABSTRACT: Colorectal cancer is the third most frequently diagnosed cancer in the world. Despite extensive studies and apparent progress in modern strategies for disease control, the treatment options are still not sufficient and effective, mostly due to frequently encountered resistance to immunotherapy of colon cancer patients in common clinical practice. In our study, we aimed to uncover the CCL9 chemokine action employing the murine model of colon cancer to seek new, potential molecular targets that could be promising in the development of colon cancer therapy. Mouse CT26.CL25 colon cancer cell line was used for introducing lentivirus-mediated CCL9 overexpression. The blank control cell line contained an empty vector, while the cell line marked as CCL9+ carried the CCL9-overexpressing vector. Nex

SUBMITTER: Lazarczyk M 

PROVIDER: S-EPMC10136558 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature