Prognostic Role of Circulating Tumor Cell Trajectories in Metastatic Colorectal Cancer.

ABSTRACT:

Background

A large amount of evidence from clinical studies has demonstrated that circulating tumor cells are strong predictors of outcomes in many cancers. However, the clinical significance of CTC enumeration in metastatic colorectal cancer is still questioned. The aim of this study was to evaluate the clinical value of CTC dynamics in mCRC patients receiving first-line treatments.

Materials and methods

Serial CTC data from 218 patients were used to identify CTC trajectory patterns during the course of treatment. CTCs were evaluated at baseline, at a first-time point check and at the radiological progression of the disease. CTC dynamics were correlated with clinical endpoints.

Results

Using a cut-off of ≥1 CTC/7.5 mL, four prognostic trajectories were outlined. The

SUBMITTER: Magri V 

PROVIDER: S-EPMC10136568 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature