HR Gene Variants Identified in Mexican Patients with Alopecia Areata.

ABSTRACT: Alopecia Areata (AA) is a multifactorial, dermatological disease characterized by non-scarring hair loss. Alterations in candidate genes, such as HR (Hairless), could represent a risk factor for its development. The aim of this study was to search for and analyze variants in exons 3, 15 and 17 of the HR gene in Mexican patients with AA. A total of 30 samples from both AA patients and healthy donors were analyzed in this study. Exons were amplified and sequenced using the Sanger method. Descriptive statistics and χ2 tests were used in the analysis of clinical-demographic characteristics and the comparison of allelic/genotypical frequencies between groups, respectively. The effect on protein function for the non-synonymous variants was determined with three bioinformatics serve

SUBMITTER: Ortiz-Ramirez A 

PROVIDER: S-EPMC10136600 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature