PARP1 Regulates Circular RNA Biogenesis though Control of Transcriptional Dynamics.

ABSTRACT: Circular RNAs (circRNAs) are a recently discovered class of RNAs derived from protein-coding genes that have important biological and pathological roles. They are formed through backsplicing during co-transcriptional alternative splicing; however, the unified mechanism that accounts for backsplicing decisions remains unclear. Factors that regulate the transcriptional timing and spatial organization of pre-mRNA, including RNAPII kinetics, the availability of splicing factors, and features of gene architecture, have been shown to influence backsplicing decisions. Poly (ADP-ribose) polymerase I (PARP1) regulates alternative splicing through both its presence on chromatin as well as its PARylation activity. However, no studies have investigated PARP1's possible role in regulating circRNA bioge

SUBMITTER: Eleazer R 

PROVIDER: S-EPMC10136798 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature