Experimental Validation and Prediction of Super-Enhancers: Advances and Challenges.

ABSTRACT: Super-enhancers (SEs) are cis-regulatory elements of the human genome that have been widely discussed since the discovery and origin of the term. Super-enhancers have been shown to be strongly associated with the expression of genes crucial for cell differentiation, cell stability maintenance, and tumorigenesis. Our goal was to systematize research studies dedicated to the investigation of structure and functions of super-enhancers as well as to define further perspectives of the field in various applications, such as drug development and clinical use. We overviewed the fundamental studies which provided experimental data on various pathologies and their associations with particular super-enhancers. The analysis of mainstream approaches for SE search and prediction allowed us to accumulate

SUBMITTER: Kravchuk EV 

PROVIDER: S-EPMC10136858 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature