Plant Antimicrobial Peptides: Insights into Structure-Function Relationships for Practical Applications.

ABSTRACT: Antimicrobial peptides (AMPs) are short polypeptide molecules produced by multicellular organisms that are involved in host defense and microbiome preservation. In recent years, AMPs have attracted attention as novel drug candidates. However, their successful use requires detailed knowledge of the mode of action and identification of the determinants of biological activity. In this review, we focused on structure-function relationships in the thionins, α-hairpinins, hevein-like peptides, and the unique Ib-AMP peptides isolated from Impatiens balsamina. We summarized the available data on the amino acid sequences and 3D structure of peptides, their biosynthesis, and their biological activity. Special attention was paid to the determination of residues that play a key role in the acti

SUBMITTER: Slezina MP 

PROVIDER: S-EPMC10136942 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature