Early Recurrence after Upfront Surgery for Pancreatic Ductal Adenocarcinoma.

ABSTRACT:

Background

Survival after surgery for pancreatic ductal adenocarcinoma (PDAC) remains poor, due to early recurrence (ER) of the disease. A global definition of ER is lacking and different cut-off values (6, 8, and 12 months) have been adopted. The aims of this study were to define the optimal cut-off for the definition of ER and predictive factors for ER.

Methods

Recurrence was recorded for all consecutive patients undergoing upfront surgery for PDAC at our institute between 2010 and 2017. Receiver operating characteristic (ROC) curves were utilized, to estimate the optimal cut-off for the definition of ER as a predictive factor for poor post-progression survival (PPS). To identify predictive factors of ER, univariable and multivariable logistic regression models were used.<

SUBMITTER: Nappo G 

PROVIDER: S-EPMC10137113 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature