Morphological and Ultrastructural Collagen Defects: Impact and Implications in Dentinogenesis Imperfecta.

ABSTRACT: Collagen is the building block for the extracellular matrix in bone, teeth and other fibrous tissues. Osteogenesis imperfecta (OI), or brittle bone disease, is a heritable disorder that results from defective collagen synthesis or metabolism, resulting in bone fragility. The dental manifestation of OI is dentinogenesis imperfecta (DI), a genetic disorder that affects dentin structure and clinical appearance, with a characteristic feature of greyish-brown discolouration. The aim of this study was to conduct a systematic review to identify and/or define any ultrastructural changes in dentinal collagen in DI. Established databases were searched: Cochrane Library, OVID Embase, OVID Medline and PubMed/Medline. Search strategies included: Collagen Ultrastructure, DI and OI. Inclusion criteria we

SUBMITTER: Gadi LSA 

PROVIDER: S-EPMC10137525 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature