Interaction between KLOTHO-VS Heterozygosity and APOE ε4 Allele Predicts Rate of Cognitive Decline in Late-Onset Alzheimer's Disease.

ABSTRACT: KLOTHO-VS heterozygosity (KL-VS^het+) promotes longevity and protects against cognitive decline in aging. To determine whether KL-VS^het+ mitigates Alzheimer's disease (AD) progression, we used longitudinal linear-mixed models to compare the rate of change in multiple cognitive measures in AD patients stratified by APOE ε4 carrier status. We aggregated data on 665 participants (208 KL-VS^het-/ε4-, 307 KL-VS^het-/ε4+, 66 KL-VS^het+/ε4-, and 84 KL-VS^het+/ε4+) from two prospective cohorts, the National Alzheimer's Coordinating Center and the Alzheimer's Disease Neuroimaging Initiative. All participants were initially diagnosed with mild cognitive imp

SUBMITTER: Chen XR 

PROVIDER: S-EPMC10137709 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature