Undersampled Diffusion-Weighted ¹²⁹Xe MRI Morphometry of Airspace Enlargement: Feasibility in Chronic Obstructive Pulmonary Disease.

ABSTRACT: Multi-b diffusion-weighted hyperpolarized gas MRI measures pulmonary airspace enlargement using apparent diffusion coefficients (ADC) and mean linear intercepts (L_m). Rapid single-breath acquisitions may facilitate clinical translation, and, hence, we aimed to develop single-breath three-dimensional multi-b diffusion-weighted ¹²⁹Xe MRI using k-space undersampling. We evaluated multi-b (0, 12, 20, 30 s/cm²) diffusion-weighted ¹²⁹Xe ADC/morphometry estimates using a fully sampled and retrospectively undersampled k-space with two acceleration-factors (AF = 2 and 3) in never-smokers and ex-smokers with chronic obstructive pulmonary disease (COPD) or alpha-one anti-trypsin deficiency (AATD). For the three sampling cases, mean ADC/L_m

SUBMITTER: Perron S 

PROVIDER: S-EPMC10137722 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature